The Seraph®-100 Microbind Affinity Blood Filter Does Not Affect Vancomycin, Tacrolimus, and Mycophenolic Acid Plasma Concentrations

Ascorbic acid supplementation does not lower plasma lipoprotein(a) concentrations.

Elevated plasma concentrations of lipoprotein(a) (Lp[a]) are associated with premature coronary heart disease (CHD). Lp(a) is a lipoprotein particle consisting of low-density lipoprotein (LDL) with apolipoprotein (apo) (a) attached to the apo B-100 component of LDL. It has been hypothesized that ascorbic acid supplementation may reduce plasma levels of Lp(a). The purpose of this study was to de...

Immunosuppression with mycophenolic acid: one size does not fit all.

Over the past decade, immunosuppression for renal transplantation has shifted from predominantly azathioprine-based regimens to those containing mycophenolic acid (MMF, CellCept) (1). In most centers, MMF is combined with cyclosporine or tacrolimus (calcineurin inhibitors) plus corticosteroid therapy. These combinations have led to unprecedented patient and graft survivals over the near term (1...

The T1405N Carbamoyl Phosphate Synthetase Polymorphism Does Not Affect Plasma Arginine Concentrations in Preterm Infants

BACKGROUND A C-to-A nucleotide transversion (T1405N) in the gene that encodes carbamoyl-phosphate synthetase 1 (CPS1) has been associated with changes in plasma concentrations of L-arginine in term and near term infants but not in adults. In preterm infants homozygosity for the CPS1 Thr1405 variant (CC genotype) was associated with an increased risk of having necrotizing enterocolitis (NEC). Pl...

Does tacrolimus, in comparison with sirolimus, increase mycophenolic acid exposure in kidney transplant recipients?

Based on their study, “Increased mycophenolic acid exposure in stable kidney transplant recipients on tacrolimus as compared with , Braun et al. concluded that mycophenolic acid (MPA) exposure is greater in those on sirolimus: implication for pharmacokinetics ” tacrolimus treated patients than in those treated with sirolimus during maintenance immunosuppression after kidney transplant and sugge...

Does tacrolimus increase mycophenolic acid exposure in kidney transplant recipients as compared to sirolimus?